毎週木曜日に、生化学の2講座を中心に、基礎分野の研究者が集まって、論文紹介をしています。

2020

Inhibition of Upf2-dependent nonsense-mediated decay leads to behavioral and neurophtsical abnormalities by activating the immune response. Neuron, 2019, 104, 665-679 (Mar 26, Ishigaki)

A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 579, 270-273 (Mar 19, Ikeda)

Structural basis for the recognition of the SARS-Cov-2 by full-length human ACE2. Science, 2020, 367, 1444-1448

Cry-EM structure of the 2019-nCoV spike in the prefusion conformation. Science, 2020, 367, 1260-1263 (Mar 12, Wada)

An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates. Cancer Cell, 2020, 37, 21-36 (Feb 13, Yoshitomi)

TGF-b orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature, 2020, 577, 566-571 (Feb 6, Yoshizaki)

Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells. Cell, 2020, 180, 107-121 (Jan 16, Fujioka)

Stabilization of chromatin topology safeguards genome integrity. Nature, 2019, 574, 571-574 (Jan 9, Matsui)

2019

TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit. Cell, 2019, 1788, 1344-1361 (Dec 12, Taniguchi)

MHC-II neoantigens shape tumor immunity and response to immunotherapy. Nature, 2019, 574, 696-701 (Nov 28, Matsuba)

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. Science, 2019, 365, 65-69 (Nov 21, Tasaki)

A complex of U1 snRNP with cleavage and polyadenylation factors controls telescripting, regulating mRNA transcription in human cells. Mol. Cell 2019, 76, 590-599 (Nov 14, Tatsuno)

The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nat. Cell Biol. 2019, 21, 1273-1285 (Nov 7, Hashimoto)

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat. medicine 2019, 25, 988-1000 (Oct 24, Takatsuji)

Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature 2019, 574, 112-116 (Oct 17, Shouji)

Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature 2019, 573, 130-134 (Oct 10, Shimada)

Dietary intake regulates the circulating inflammatory monocyte pool. Cell 2019, 178, 1102-1114 (Oct 3, Saito)

A Public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen. Cell 2019, 177, 1583-1599 (Sep 26, Onai)

Environmental oxygen exposure allows for the evolution of interdigital cell death in limb patterning. Developmental Cell 2019, 50, 155-166 (Sep 19, Sakai)

Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nat. commun. 2019, 10:895 (Sep 12, Sakasai)

Augmented manipulation ability in humans with six-fingered hands. Nat. commun. 2019,

10:2401 (Sep 5, Okuda)

Loss of H3K27me3 imprinting in somatic cell nuclear transfer embryos disrupts post-implantation development. Cell Stem Cell 2018, 23 343-354 (Jul 11, Ohtsuka) 

WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature 2019, 568, 551-556 (Jul 4, Iwabuchi)

Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decay. Mol. Cell 2019, 75, 1-16 (Jun 27, Ishigaki)

An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nat. Cell Biol. 2019, 21, 420-429 (Jun 13, Yoshitomi)

Glia maturation factor-gamma regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. blood advances 2019, 3, 1211-1225 (Jun 6, Wada)

Genetic compensation triggered by mutant mRNA degradation. Nature 2019, 568, 193-197 (May 30, Yonekura) 

Insulin receptor associates with promoters genome-wide and regulates gene expression. Cell 2019, 177, 722-736 (May 23, Ikeda)

A nuclear phosphoinositide kinase complex regulates p53. Choi et al., Nat. Cell Biol. 2019, 21, 462-475 (May 9, Yoshizaki) 

TRPM2 silencing causes G2/M arrest and apoptosis in lung cancer cells via increasing intracellular ROS and RNS levels and activating the JNK pathway. Almasi et al., Cell Physiol. Biochem. 2019, 52, 742-757 (Apr 25, Yamada)

Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 2019, 176, 13400-1355 (Apr 18, Matsuba)

Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function. J. Cell Biol. 2019, 208, 422-432 (Apr 11, Matsui)

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage. Nat. Cell Biol. 2019, 21, 487 (Apr 4, Hashimoto)

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat. commun. 2018, 9, 4149 (Mar 28, Taniguchi)

eIF4A3 phosphorylation by CDKs affects NMD during the cell cycle. Cell Rep. 2019, 26, 2126-2139.e9 (Mar 14, Tatsuno)

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development 2019, 146, dev174037 (Mar 7, Shouji)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature 2019, 565, 600 (Feb 28, Saito)

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science 2018, 362, eaat0174 (Feb 14, Tasaki)

VGF function in depression and antidepressant efficacy. Mol Psychiatry 2018, 23, 1632 (Jan 31, Takatsuji)

Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature 2019, 565, 180 (Jan 17, Shimada)

Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell 2019, 176, 1 (Jan 10, Onai)

2018

Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair. Genome Res. 2018, 28, 223 (Dec 20, Sakasai)

Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction. J Am Coll Cardiol 2018, 71, 263 (Dec 13, Okuda)

Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature 2017, 548, 224 (Dec 6, Ohtsuka)

NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides. Nat. Struct. Mol. Biol. 2018, 25, 940 (Nov 22, Ishigaki)

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat. commun. 2018, 9, 1249 (Nov 15, Iwabuchi) 

Protein AMPylation by an evolutionarily conserved pseudokinase. Cell 2018, 175, 809 (Nov 8, Ikeda)

Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods. Nat. ecology&evolution 2017, 1, 1392. (Nov 1, Arikawa)

Parkin and PINK1 mitigate STING-induced inflammation. Nature 2018, 561, 258. (Oct 25, Wada)

Widespread intronic polyadenylation inactivates tumor suppressor genes in leukeamia. Nature 2018, 561, 127. (Oct 18, Yonekura)